Spinal HDAC6 mediates nociceptive behaviors induced by chronic constriction injury via neuronal activation and neuroinflammation.

Sun, Kai; Zhang, Hao; Zhang, Ting; Sun, Nan; Hao, Jingru; Wang, Zhiping; Gao, Can

Sun, Kai; Zhang, Hao; Zhang, Ting; Sun, Nan; Hao, Jingru; Wang, Zhiping; Gao, Can.

Afiliação

Sun K; Nanjing Medical University, Nanjing, China.
Zhang H; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Jiangsu Province Key Laboratory of Anesthesiology, Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application, Xuzhou Medical University, Xuzhou, China.
Zhang T; Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Sun N; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Jiangsu Province Key Laboratory of Anesthesiology, Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application, Xuzhou Medical University, Xuzhou, China.
Hao J; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Jiangsu Province Key Laboratory of Anesthesiology, Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application, Xuzhou Medical University, Xuzhou, China.
Wang Z; Department of Pain Management, Xuzhou Central Hospital, Xuzhou, China.
Gao C; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Jiangsu Province Key Laboratory of Anesthesiology, Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application, Xuzhou Medical University, Xuzhou, China.

Mol Pain ; 19: 17448069231218352, 2023.

Article em En | MEDLINE | ID: mdl-37982151

Assuntos

Hiperalgesia; Neuralgia; Ratos; Animais; Hiperalgesia/tratamento farmacológico; Hiperalgesia/metabolismo; Ratos Sprague-Dawley; Doenças Neuroinflamatórias; Constrição; Nociceptividade; Neuralgia/metabolismo; Medula Espinal/metabolismo; Inflamação/metabolismo; Neurônios/metabolismo; Desacetilase 6 de Histona/metabolismo

Palavras-chave

HDAC6; inflammation; microglia; neuron; neuropathic pain; spinal cord

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hiperalgesia / Neuralgia Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hiperalgesia / Neuralgia Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article