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Human Circovirus is not detected in plasma pools for fractionation.
Pérot, Philippe; Da Rocha, Nicolas; Farcet, Maria R; Kreil, Thomas R; Eloit, Marc.
Afiliação
  • Pérot P; Pathogen Discovery Laboratory, Institut Pasteur, Université Paris Cité, Paris, France.
  • Da Rocha N; Institut Pasteur, Université Paris Cité, The WOAH (OIE) Collaborating Center for the detection and identification in humans of emerging animal pathogens, Paris, France.
  • Farcet MR; Pathogen Discovery Laboratory, Institut Pasteur, Université Paris Cité, Paris, France.
  • Kreil TR; Institut Pasteur, Université Paris Cité, The WOAH (OIE) Collaborating Center for the detection and identification in humans of emerging animal pathogens, Paris, France.
  • Eloit M; Global Pathogen Safety, Takeda Manufacturing Austria AG, Vienna, Austria.
Transfusion ; 64(1): 16-18, 2024 01.
Article em En | MEDLINE | ID: mdl-37982366
ABSTRACT

BACKGROUND:

Human Circovirus 1 and 2 were recently described in a French hepatitis case and in two Chinese drug users. Because of its small size and presumable high resistance to both inactivation and removal by nanofilters, such viruses-if determined to be even pathogenic-should be considered with respect to the safety of plasma derivatives. We, therefore, investigated the prevalence and titer of these viruses in plasma pools before fractionation. METHODS AND MATERIALS We tested for the presence of Human Circovirus 1 and 2 by qPCR in 48 plasma pools derived from healthy donors from Europe, USA, and Japan, corresponding to more than 200,000 plasma donations.

RESULTS:

We did not detect the presence of Human Circovirus 1 and 2 in any of the plasma pools, with a limit of detection of 300-600 genome copies per mL of plasma.

CONCLUSIONS:

These results indicate that high levels of circovirus are not widely prevalent in such donations.
Assuntos
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Circovirus Limite: Humans País como assunto: Asia / Europa Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Circovirus Limite: Humans País como assunto: Asia / Europa Idioma: En Ano de publicação: 2024 Tipo de documento: Article