Discovery of small molecule c-Maf inhibitors using molecular docking-based virtual screening, molecular dynamics simulation, and biological evaluation.

Hu, Zhiwei; Zeng, Yindi; Zhang, Yaxin; Zhang, Qiurong; Xu, Jinge; Liu, Linlin

Hu, Zhiwei; Zeng, Yindi; Zhang, Yaxin; Zhang, Qiurong; Xu, Jinge; Liu, Linlin.

Afiliação

Hu Z; College of Medical Imaging, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Zeng Y; Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Zhang Y; Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Zhang Q; The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Xu J; The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Liu L; College of Medical Imaging, Xuzhou Medical University, Xuzhou, Jiangsu, China.

Chem Biol Drug Des ; 103(1): e14403, 2024 01.

Article em En | MEDLINE | ID: mdl-37984986

Assuntos

Simulação de Dinâmica Molecular; Mieloma Múltiplo; Compostos de Sulfonilureia; Humanos; Simulação de Acoplamento Molecular; Sorafenibe/farmacologia; Mieloma Múltiplo/tratamento farmacológico; Proteínas Proto-Oncogênicas c-maf

Palavras-chave

c-Maf; molecular docking-based virtual screening; molecular dynamics simulation; multiple myeloma

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Sulfonilureia / Simulação de Dinâmica Molecular / Mieloma Múltiplo Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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