Administration of a glypican-3 peptide increases the infiltration and cytotoxicity of CD8<sup>+</sup> T cells against testicular yolk sac tumor, associated with enhancing the intratumoral cGAS/STING signaling.

Zhao, Junfeng; Qin, Le; He, Guorong; Xie, Tiancheng; Hu, Guanghui; Wang, Furan; Zhong, Hongji; Zhu, Jianming; Xu, Yunfei

Administration of a glypican-3 peptide increases the infiltration and cytotoxicity of CD8⁺ T cells against testicular yolk sac tumor, associated with enhancing the intratumoral cGAS/STING signaling.

Zhao, Junfeng; Qin, Le; He, Guorong; Xie, Tiancheng; Hu, Guanghui; Wang, Furan; Zhong, Hongji; Zhu, Jianming; Xu, Yunfei.

Afiliação

Zhao J; Department of Urology, Shanghai Tenth People's Hospital, School of Medicine in Tongji University, Shanghai, China.
Qin L; Department of Pediatrics Surgery, Ningbo Women and Children's Hospital, Ningbo, China.
He G; Department of Pediatrics Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Xie T; Department of Pediatrics Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Hu G; Department of Urology, Shanghai Tenth People's Hospital, School of Medicine in Tongji University, Shanghai, China.
Wang F; Department of Urology, Renji Hospital, School of Medicine in Shanghai Jiaotong University, Shanghai, China.
Zhong H; Department of Pediatrics Surgery, Ningbo Women and Children's Hospital, Ningbo, China.
Zhu J; Department of Pediatrics Surgery, Ningbo Women and Children's Hospital, Ningbo, China.
Xu Y; Department of Pediatrics Surgery, Ningbo Women and Children's Hospital, Ningbo, China.

Cancer Med ; 12(23): 21293-21307, 2023 12.

Article em En | MEDLINE | ID: mdl-37986544

Assuntos

Tumor do Seio Endodérmico; Neoplasias Testiculares; Masculino; Humanos; Linfócitos T CD8-Positivos; Granzimas/metabolismo; Tumor do Seio Endodérmico/metabolismo; Glipicanas/metabolismo; Peptídeos/metabolismo; Neoplasias Testiculares/metabolismo; Nucleotidiltransferases

Palavras-chave

cGAS/STING signaling; glypican-3; immunotherapy; peptide vaccine; yolk sac tumor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Testiculares / Tumor do Seio Endodérmico Limite: Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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