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Cognitive Reserve proxies can modulate motor and non-motor basal ganglia circuits in early Parkinson's Disease.
Di Tella, Sonia; Isernia, Sara; Cabinio, Monia; Rossetto, Federica; Borgnis, Francesca; Pagliari, Chiara; Cazzoli, Marta; Navarro, Jorge; Silveri, Maria Caterina; Baglio, Francesca.
Afiliação
  • Di Tella S; Department of Psychology, Università Cattolica del Sacro Cuore, Milan, Italy.
  • Isernia S; IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy.
  • Cabinio M; IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy. sisernia@dongnocchi.it.
  • Rossetto F; IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy.
  • Borgnis F; IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy.
  • Pagliari C; IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy.
  • Cazzoli M; IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy.
  • Navarro J; IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy.
  • Silveri MC; IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy.
  • Baglio F; Department of Psychology, Università Cattolica del Sacro Cuore, Milan, Italy.
Brain Imaging Behav ; 18(1): 220-230, 2024 Feb.
Article em En | MEDLINE | ID: mdl-37993754
Parkinson's Disease (PD) is hallmarked by dysfunctional circuitry between the basal ganglia and dorsolateral-prefrontal cortex. Recently progress has been made in understanding factors contributing to differential susceptibility to pathology mitigating disease-related cognitive decline. Cognitive reserve, the brain processing resources accumulated throughout life while engaged in mentally stimulating activities, can play an important protective role in cognitive performance. We tested the hypothesis that Cognitive Reserve proxies may exert an impact on the basal ganglia and dorsolateral-prefrontal atrophy in early PD. Forty-five early patients with PD and 20 age-gender-matched healthy controls (HC) completed the Cognitive Reserve Index questionnaire to quantify Cognitive Reserve proxies by three indexes (CRI-Education, CRI-Working Activity, CRI-Leisure Time) and a structural MRI examination (3T). Morphometrical indexes for basal ganglia (bilateral putamen, caudate, pallidum volume) and dorsolateral-prefrontal cortex (cortical thickness) were computed. Significant differences between HC and PD were tested by direct comparisons in demographics, cognitive level, and cognitive reserve proxies indexes. Then two multiple regression analyses were performed to identify predictors of the basal ganglia and dorsolateral-prefrontal cortex structural integrity. Regression analysis revealed that basal ganglia volume was significantly predicted by CRI-Education (pFDR = 0.029), sex (pFDR = 0.029), and Total Intracranial Volume (pFDR < 0.001). Instead, the dorsolateral-prefrontal thickness was predicted by CRI-Leisure Time (pFDR = 0.030) and age (pFDR = 0.010). Cognitive Reserve proxies, especially education and leisure-time activities, can play a protective role on the structural integrity of the basal ganglia and dorsolateral-prefrontal cortex, respectively, critical regions hallmarking brain status of early phases of PD.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Reserva Cognitiva Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Reserva Cognitiva Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article