Development and post-Kasai procedure prognostic relevance of histological features for biliary atresia.
BMC Pediatr
; 23(1): 589, 2023 11 22.
Article
em En
| MEDLINE
| ID: mdl-37993876
ABSTRACT
OBJECTIVES:
To validate an appropriate evaluation method of liver fibrosis assessment based on the unique pathological features of biliary atresia (BA) that could well predict its prognosis.METHODS:
A total of 68 patients with BA who underwent Kasai procedure (KP) and an intraoperative liver biopsy, followed up from January 2019 to December 2021, were recruited in a retrospective analysis. Ishak, Metavir, and BA-specific staging systems in relation to outcomes were analyzed using logistic regression, COX proportional hazard regression, Kaplan-Meier analysis, etc.RESULTS:
Kaplan-Meier analysis determined a significant difference in native liver survival according to the BA-specific stage (p = 0.002). The ROC curve analysis for predicting prognosis showed that the AUC of BA-specific staging combined with iBALF and severe bile duct proliferation (BDP) (0.811, 95% CI 0.710-0.913, p < 0.0001) was higher than BA-specific staging alone (0.755, 95% CI 0.639-0.872, p < 0.001).CONCLUSIONS:
The BA-specific staging system reflects the condition of the liver fibrosis, and its combination with iBALF and severe BDP helps to better evaluate the prognosis of patients with BA.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Atresia Biliar
Limite:
Humans
/
Infant
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article