A novel intronic circular RNA circFGFR1<sup>int2</sup> up-regulates FGFR1 by recruiting transcriptional activators P65/FUS and suppressing miR-4687-5p to promote prostate cancer progression.

Wang, Ruyue; Zhong, Jinjing; Pan, Xiuyi; Su, Zhengzheng; Xu, Yunyi; Zhang, Mengni; Chen, Xueqin; Chen, Ni; Yu, Ting; Zhou, Qiao

A novel intronic circular RNA circFGFR1^int2 up-regulates FGFR1 by recruiting transcriptional activators P65/FUS and suppressing miR-4687-5p to promote prostate cancer progression.

Wang, Ruyue; Zhong, Jinjing; Pan, Xiuyi; Su, Zhengzheng; Xu, Yunyi; Zhang, Mengni; Chen, Xueqin; Chen, Ni; Yu, Ting; Zhou, Qiao.

Afiliação

Wang R; Department of Pathology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Zhong J; Department of Pathology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Pan X; Department of Pathology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Su Z; Department of Pathology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Xu Y; Department of Pathology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Zhang M; Department of Pathology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Chen X; Department of Pathology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Chen N; Department of Pathology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Yu T; Department of Pathology, West China Hospital, Sichuan University, Chengdu, 610041, China. yuting_hx@scu.edu.cn.
Zhou Q; Department of Pathology, West China Hospital, Sichuan University, Chengdu, 610041, China. zhouqiao@scu.edu.cn.

J Transl Med ; 21(1): 840, 2023 11 22.

Article em En | MEDLINE | ID: mdl-37993879

Assuntos

MicroRNAs; Neoplasias da Próstata; Masculino; Humanos; Receptor Tipo 1 de Fator de Crescimento de Fibroblastos/genética; Receptor Tipo 1 de Fator de Crescimento de Fibroblastos/metabolismo; RNA Circular/genética; Íntrons/genética; Fosfatidilinositol 3-Quinases/metabolismo; Neoplasias da Próstata/patologia; Proliferação de Células/genética; MicroRNAs/genética; MicroRNAs/metabolismo; Linhagem Celular Tumoral; Regulação Neoplásica da Expressão Gênica; Proteína FUS de Ligação a RNA/genética; Proteína FUS de Ligação a RNA/metabolismo

Palavras-chave

FGFR1; FUS; P65; Prostate cancer; Transcription regulation; circRNA; miRNA

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / MicroRNAs Limite: Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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