Morphogens enable interacting supracellular phases that generate organ architecture.
Science
; 382(6673): eadg5579, 2023 11 24.
Article
em En
| MEDLINE
| ID: mdl-37995219
During vertebrate organogenesis, increases in morphological complexity are tightly coupled to morphogen expression. In this work, we studied how morphogens influence self-organizing processes at the collective or "supra"-cellular scale in avian skin. We made physical measurements across length scales, which revealed morphogen-enabled material property differences that were amplified at supracellular scales in comparison to cellular scales. At the supracellular scale, we found that fibroblast growth factor (FGF) promoted "solidification" of tissues, whereas bone morphogenetic protein (BMP) promoted fluidity and enhanced mechanical activity. Together, these effects created basement membrane-less compartments within mesenchymal tissue that were mechanically primed to drive avian skin tissue budding. Understanding this multiscale process requires the ability to distinguish between proximal effects of morphogens that occur at the cellular scale and their functional effects, which emerge at the supracellular scale.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vertebrados
/
Proteínas Morfogenéticas Ósseas
/
Organogênese
/
Plumas
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article