Protective effect of arctiin against Toxoplasma gondii HSP70-induced allergic acute liver injury by disrupting the TLR4-mediated activation of cytosolic phospholipase A<sub>2</sub> and platelet-activating factor.

Lu, Jing-Mei; Xu, Xiang; Aosai, Fumie; Zhang, Ming-Yue; Zhou, Lu-Lu; Piao, Lian-Xun

Protective effect of arctiin against Toxoplasma gondii HSP70-induced allergic acute liver injury by disrupting the TLR4-mediated activation of cytosolic phospholipase A₂ and platelet-activating factor.

Lu, Jing-Mei; Xu, Xiang; Aosai, Fumie; Zhang, Ming-Yue; Zhou, Lu-Lu; Piao, Lian-Xun.

Afiliação

Lu JM; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji 133002, Jilin Province, China.
Xu X; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji 133002, Jilin Province, China.
Aosai F; Department of Infection and Host Defense, Graduate School of Medicine, Shinshu University, Matsumoto, Japan.
Zhang MY; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji 133002, Jilin Province, China.
Zhou LL; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji 133002, Jilin Province, China.
Piao LX; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji 133002, Jilin Province, China. Electronic address: lxpiao@ybu.edu.cn.

Int Immunopharmacol ; 126: 111254, 2024 Jan 05.

Article em En | MEDLINE | ID: mdl-37995571

Assuntos

Toxoplasma; Toxoplasmose; Animais; Camundongos; Toxoplasma/metabolismo; Receptor 4 Toll-Like/metabolismo; Fator de Ativação de Plaquetas; Toxoplasmose/tratamento farmacológico; Proteínas de Choque Térmico HSP70/metabolismo; Fígado/metabolismo; Fosfolipases/metabolismo

Palavras-chave

Allergic liver injury; Arctiin; T. gondii HSP70; TLR4; Toxoplasma gondii; cPLA(2)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Toxoplasma / Toxoplasmose Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Toxoplasma / Toxoplasmose Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article