M1 and M2 Macrophages Differentially Regulate Colonic Crypt Renewal.

Raveenthiraraj, Sathuwarman; Awanis, Griselda; Chieppa, Marcello; O'Connell, Amy E; Sobolewski, Anastasia

Raveenthiraraj, Sathuwarman; Awanis, Griselda; Chieppa, Marcello; O'Connell, Amy E; Sobolewski, Anastasia.

Afiliação

Raveenthiraraj S; School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, Norfolk, NR4 7TJ, UK.
Awanis G; Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Chieppa M; School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, Norfolk, NR4 7TJ, UK.
O'Connell AE; Department of Biological and Environmental Sciences and Technologies, University of Solento, Centro Ecotekne, 73043, Monteroni, Lecce, Italy.
Sobolewski A; Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.

Inflamm Bowel Dis ; 2023 Nov 24.

Article em En | MEDLINE | ID: mdl-38001043

Inflammatory macrophages but not homeostatic macrophages modulate crypt epithelial cell differentiation. Direct physical contact between an inflammatory macrophage and the crypt epithelium is required for regulation of differentiation, but crypt proliferation is via a secreted factor.

Palavras-chave

Lgr5; colon; inflammation; macrophages; stem cells

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links