Resensitizing Paclitaxel-Resistant Ovarian Cancer via Targeting Lipid Metabolism Key Enzymes CPT1A, SCD and FASN.

Ma, Qinsiyu; Liu, Zhan'ao; Wang, Tengyu; Zhao, Pengfei; Liu, Mingrui; Wang, Yifang; Zhao, Weitong; Yuan, Ying; Li, Shuo

Ma, Qinsiyu; Liu, Zhan'ao; Wang, Tengyu; Zhao, Pengfei; Liu, Mingrui; Wang, Yifang; Zhao, Weitong; Yuan, Ying; Li, Shuo.

Afiliação

Ma Q; Department of Biochemistry & Molecular Biology, School of Life Sciences, China Medical University, Shenyang 110122, China.
Liu Z; Department of Biochemistry & Molecular Biology, School of Life Sciences, China Medical University, Shenyang 110122, China.
Wang T; Department of Biochemistry & Molecular Biology, School of Life Sciences, China Medical University, Shenyang 110122, China.
Zhao P; Department of Biochemistry & Molecular Biology, School of Life Sciences, China Medical University, Shenyang 110122, China.
Liu M; Department of Biochemistry & Molecular Biology, School of Life Sciences, China Medical University, Shenyang 110122, China.
Wang Y; Department of Biochemistry & Molecular Biology, School of Life Sciences, China Medical University, Shenyang 110122, China.
Zhao W; Department of Biochemistry & Molecular Biology, School of Life Sciences, China Medical University, Shenyang 110122, China.
Yuan Y; Department of Biochemistry & Molecular Biology, School of Life Sciences, China Medical University, Shenyang 110122, China.
Li S; Department of Biochemistry & Molecular Biology, School of Life Sciences, China Medical University, Shenyang 110122, China.

Int J Mol Sci ; 24(22)2023 Nov 19.

Article em En | MEDLINE | ID: mdl-38003694

Assuntos

Neoplasias Ovarianas; Paclitaxel; Humanos; Feminino; Paclitaxel/farmacologia; Paclitaxel/uso terapêutico; Neoplasias Ovarianas/tratamento farmacológico; Neoplasias Ovarianas/genética; Neoplasias Ovarianas/metabolismo; Linhagem Celular Tumoral; Metabolismo dos Lipídeos/genética; Resistencia a Medicamentos Antineoplásicos/genética; Carcinoma Epitelial do Ovário/tratamento farmacológico; Carcinoma Epitelial do Ovário/genética; Apoptose/genética; Ácido Graxo Sintase Tipo I/metabolismo

Palavras-chave

CPT1A; FASN; SCD; epithelial ovarian cancer; lipid metabolism; paclitaxel resistance

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Paclitaxel Limite: Female / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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