Metal-Free Catalyzed Oxidation/Decarboxylative [3+2] Cycloaddition Sequences of 3-Formylchromones to Access Pyrroles with Anti-Cancer Activity.
Molecules
; 28(22)2023 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-38005323
ABSTRACT
An efficient and direct approach to pyrroles was successfully developed by employing 3-formylchromones as decarboxylative coupling partners, and facilitated by microwave irradiation. The protocol utilizes easily accessible feedstocks, a catalytic amount of DBU without any metals, resulting in high efficiency and regioselectivity. Notably, all synthesized products were evaluated against five different cancer cell lines and compound 3l selectively inhibited the proliferation of HCT116 cells with an IC50 value of 10.65 µM.
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Base de dados:
MEDLINE
Assunto principal:
Pirróis
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Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article