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Inhibiting NR5A2 targets stemness in pancreatic cancer by disrupting SOX2/MYC signaling and restoring chemosensitivity.
Zheng, Quan; Tang, Jiajia; Aicher, Alexandra; Bou Kheir, Tony; Sabanovic, Berina; Ananthanarayanan, Preeta; Reina, Chiara; Chen, Minchun; Gu, Jian-Min; He, Bin; Alcala, Sonia; Behrens, Diana; Lawlo, Rita T; Scarpa, Aldo; Hidalgo, Manuel; Sainz, Bruno; Sancho, Patricia; Heeschen, Christopher.
Afiliação
  • Zheng Q; Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
  • Tang J; State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Aicher A; Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
  • Bou Kheir T; State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Sabanovic B; Precision Immunotherapy, Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
  • Ananthanarayanan P; Immunology Research and Development Center, China Medical University, Taichung, Taiwan.
  • Reina C; Barts Cancer Institute, Queen Mary University of London, London, UK.
  • Chen M; Pancreatic Cancer Heterogeneity Lab, Candiolo Cancer Institute - FPO - IRCCS, Candiolo, Turin, Italy.
  • Gu JM; Pancreatic Cancer Heterogeneity Lab, Candiolo Cancer Institute - FPO - IRCCS, Candiolo, Turin, Italy.
  • He B; Pancreatic Cancer Heterogeneity Lab, Candiolo Cancer Institute - FPO - IRCCS, Candiolo, Turin, Italy.
  • Alcala S; Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
  • Behrens D; State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Lawlo RT; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Scarpa A; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China.
  • Hidalgo M; Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
  • Sainz B; Instituto de Investigaciones Biomédicas "Alberto Sols" CSIC-UAM, Chronic Diseases and Cancer Area 3 Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Centro de Investigación Biomédica en Red, Área Cáncer, CIBERONC, ISCIII, Madrid, Spain.
  • Sancho P; Experimental Pharmacology and Oncology Berlin-Buch GmbH, Berlin, Germany.
  • Heeschen C; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy.
J Exp Clin Cancer Res ; 42(1): 323, 2023 Nov 28.
Article em En | MEDLINE | ID: mdl-38012687
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Carcinoma Ductal Pancreático Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Carcinoma Ductal Pancreático Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article