Limonoids and alkaloids from Tetradium austrosinense (Hand.-Mazz.) T.G.Hartley.
Fitoterapia
; 172: 105759, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-38013059
ABSTRACT
A pair of new enantiomeric indolopyridoquinazoline-type alkaloids, (+)-1,7S,8R- and (-)-1,7R,8S-trihydroxyrutaecarpine (3a and 3b), and a new limonoid-tyrosamine hybrid, austrosinin (8), along with six known alkaloids and limonoids, were isolated from the stems with leaves of Tetradium austrosinense. Their structures were elucidated on the basis of analysis of MS, NMR, ECD and time-dependent density functional theory-based electronic circular dichroism (TDDFT-ECD) calculations, as well as proposed biosynthetic pathway. An anti-inflammatory bioassay in vitro showed 8 had significant immunosuppressive effect against the production of pro-inflammatory cytokine TNF-α in lipopolysaccharide (LPS)-stimulated RAW264.7 cells.
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Base de dados:
MEDLINE
Assunto principal:
Rutaceae
/
Limoninas
/
Alcaloides
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article