Hyper-physiologic mechanical cues, as an osteoarthritis disease relevant environmental perturbation, cause a critical shift in set-points of methylation at transcriptionally active CpG sites in neo-cartilage organoids. | Res Sq;2023 Nov 15. | MEDLINE

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Hyper-physiologic mechanical cues, as an osteoarthritis disease relevant environmental perturbation, cause a critical shift in set-points of methylation at transcriptionally active CpG sites in neo-cartilage organoids.

Bloks, Niek Gc; Dicks, Amanda; Harissa, Zainab; Nelissen, Rob Ghh; Hajmousa, Ghazaleh; Ramos, Yolande Fm; Almeida, Rodrigo Coutinho; Guilak, Farshid; Meulenbelt, Ingrid.

Afiliação

Bloks NG; Leiden University Medical Center.
Dicks A; Washington University in St. Louis.
Harissa Z; Washington University in St. Louis.
Nelissen RG; Leiden University Medical Center.
Hajmousa G; Leiden University Medical Center.
Ramos YF; Leiden University Medical Center.
Almeida RC; Leiden University Medical Center.
Guilak F; Washington University in St. Louis.
Meulenbelt I; Leiden University Medical Center.

Res Sq ; 2023 Nov 15.

Article em En | MEDLINE | ID: mdl-38014245

Palavras-chave

Chondrocytes; DNA Methylation; Environmental stressors; Mechanical Loading; Osteoarthritis

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article