Circadian Clock Dysregulation and Prostate Cancer: A Molecular and Clinical Overview.

Kaakour, Dalia; Fortin, Bridget; Masri, Selma; Rezazadeh, Arash.

Afiliação

Kaakour D; Division of Hematology/Oncology, Department of Medicine, University of California, Irvine, Orange, CA, USA.
Fortin B; Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Masri S; Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Rezazadeh A; Division of Hematology/Oncology, Department of Medicine, University of California, Irvine, Orange, CA, USA.

Clin Med Insights Oncol ; 17: 11795549231211521, 2023.

Article em En | MEDLINE | ID: mdl-38033743

ABSTRACT

Circadian clock dysregulation has been implicated in various types of cancer and represents an area of growing research. However, the role of the circadian clock in prostate cancer has been relatively unexplored. This literature review will highlight the potential role of circadian clock dysregulation in prostate cancer by examining molecular, epidemiologic, and clinical data. The influence of melatonin, light, night shift work, chronotherapy, and androgen independence are discussed as they relate to the existing literature on their role in prostate cancer.

Palavras-chave

Prostate cancer; circadian rhythm; clock dysregulation; oncogenesis; shift work

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article