The Lateral Parabrachial Nucleus Inputs to the Lateral Hypothalamus Trigger Nocifensive Behaviors.
Neuroscience
; 537: 12-20, 2024 Jan 26.
Article
em En
| MEDLINE
| ID: mdl-38036057
ABSTRACT
The lateral parabrachial nucleus (LPBN) is known to play a key role in relaying noxious information from the spinal cord to the brain. Different LPBN efferent mediate different aspects of the nocifensive response. However, the function of the LPBN â lateral hypothalamus (LH) circuit in response to noxious stimuli has remained unknown. Here, we show that LPBN â LH circuit is activated by noxious stimuli. Interestingly, either activation or inhibition of this circuit induced analgesia. Optogenetic activation of LPBN afferents in the LH elicited spontaneous jumping and induced place aversion. Optogenetic inhibition inhibited jumping behavior to noxious heat. Ablation of LH glutamatergic neurons could abolish light-evoked analgesia and jumping behavior. Our study revealed a role for the LPBN â LH pathway in nocifensive behaviors.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Núcleos Parabraquiais
/
Região Hipotalâmica Lateral
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article