Classical swine fever virus NS5A protein activates autophagy via the PP2A-DAPK3-Beclin 1 axis.
J Virol
; 97(12): e0098823, 2023 Dec 21.
Article
em En
| MEDLINE
| ID: mdl-38038430
ABSTRACT
IMPORTANCE Autophagy is a conserved degradation process that maintains cellular homeostasis and regulates native and adaptive immunity. Viruses have evolved diverse strategies to inhibit or activate autophagy for their benefit. The paper reveals that CSFV NS5A mediates the dissociation of PP2A from Beclin 1 and the association of PP2A with DAPK3 by interaction with PPP2R1A and DAPK3, PP2A dephosphorylates DAPK3 to activate its protein kinase activity, and activated DAPK3 phosphorylates Beclin 1 to trigger autophagy, indicating that NS5A activates autophagy via the PP2A-DAPK3-Beclin 1 axis. These data highlight a novel mechanism by which CSFV activates autophagy to favor its replication, thereby contributing to the development of antiviral strategies.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autofagia
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Proteínas não Estruturais Virais
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Peste Suína Clássica
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Vírus da Febre Suína Clássica
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article