Neuroprotective effects of oral metformin before stroke on cerebral small-vessel disease.

Akiyama, Natsuki; Yamashiro, Takayuki; Ninomiya, Itaru; Uemura, Masahiro; Hattori, Yorito; Ihara, Masafumi; Onodera, Osamu; Kanazawa, Masato

Akiyama, Natsuki; Yamashiro, Takayuki; Ninomiya, Itaru; Uemura, Masahiro; Hattori, Yorito; Ihara, Masafumi; Onodera, Osamu; Kanazawa, Masato.

Afiliação

Akiyama N; Departments of Neurology, Brain Research Institute, Niigata University, 1-757 Asahimachi-dori, Niigata 951-8585, Japan.
Yamashiro T; Department of Neurology, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565, Japan.
Ninomiya I; Departments of Neurology, Brain Research Institute, Niigata University, 1-757 Asahimachi-dori, Niigata 951-8585, Japan.
Uemura M; Departments of Neurology, Brain Research Institute, Niigata University, 1-757 Asahimachi-dori, Niigata 951-8585, Japan.
Hattori Y; Department of Neurology, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565, Japan.
Ihara M; Department of Neurology, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, Osaka 564-8565, Japan.
Onodera O; Departments of Neurology, Brain Research Institute, Niigata University, 1-757 Asahimachi-dori, Niigata 951-8585, Japan.
Kanazawa M; Departments of Neurology, Brain Research Institute, Niigata University, 1-757 Asahimachi-dori, Niigata 951-8585, Japan. Electronic address: masa2@bri.niigata-u.ac.jp.

J Neurol Sci ; 456: 122812, 2024 Jan 15.

Article em En | MEDLINE | ID: mdl-38043334

Assuntos

Isquemia Encefálica; Diabetes Mellitus Tipo 2; AVC Isquêmico; Metformina; Fármacos Neuroprotetores; Acidente Vascular Cerebral; Humanos; Metformina/uso terapêutico; Diabetes Mellitus Tipo 2/complicações; Diabetes Mellitus Tipo 2/tratamento farmacológico; Fármacos Neuroprotetores/uso terapêutico; Acidente Vascular Cerebral/diagnóstico por imagem; Acidente Vascular Cerebral/tratamento farmacológico; Acidente Vascular Cerebral/etiologia; Hipoglicemiantes/uso terapêutico; Resultado do Tratamento; Isquemia Encefálica/complicações; Isquemia Encefálica/tratamento farmacológico

Palavras-chave

Acute ischemic stroke; Functional outcome; Metformin; Neurological severity; Small-vessel disease

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Isquemia Encefálica / Fármacos Neuroprotetores / Acidente Vascular Cerebral / Diabetes Mellitus Tipo 2 / AVC Isquêmico / Metformina Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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