MiR-29a mediates the apoptotic effects of TNF-&#945; on endothelial cells through inhibiting PI3K/AKT/BCL-2 axis.

Cao, Yunchang; Wen, Hongbo; Leng, Chaoqun; Feng, Shaolong

MiR-29a mediates the apoptotic effects of TNF-α on endothelial cells through inhibiting PI3K/AKT/BCL-2 axis.

Cao, Yunchang; Wen, Hongbo; Leng, Chaoqun; Feng, Shaolong.

Afiliação

Cao Y; Department of Molecular Biology, School of Intelligent Medicine and Biotechnology, Guilin Medical University, Guilin, China.
Wen H; Department of Biochemistry and Molecular Biology, Hengyang Medicine School, University of South China, Hengyang, China.
Leng C; Department of Biochemistry and Molecular Biology, Hengyang Medicine School, University of South China, Hengyang, China.
Feng S; The Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Heath, School of Public Health, Guilin Medical University, Guilin, China.

J Biochem Mol Toxicol ; 38(1): e23598, 2024 Jan.

Article em En | MEDLINE | ID: mdl-38047396

Assuntos

Aterosclerose; MicroRNAs; Humanos; Fator de Necrose Tumoral alfa/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Células Endoteliais da Veia Umbilical Humana/metabolismo; MicroRNAs/genética; MicroRNAs/metabolismo; Proteínas Proto-Oncogênicas c-bcl-2/metabolismo; Apoptose; Inflamação/metabolismo; Aterosclerose/metabolismo

Palavras-chave

apoptosis; atherosclerosis (AS); human umbilical vascular endothelial cells (HUVECs); microRNA (miR)-29a; tumor necrosis factor (TNF)-α

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: MicroRNAs / Aterosclerose Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: MicroRNAs / Aterosclerose Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article