Effectiveness of plant-based hand sanitizer incorporating Quercus infectoria gall extract.
J Appl Microbiol
; 134(12)2023 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-38049377
ABSTRACT
AIMS:
Quercus infectoria (Qi), a traditional herbal plant with a broad spectrum of activities on multidrug-resistant bacteria, has been developed for hand sanitizer applications. METHODS ANDRESULTS:
Antimicrobial activity was evaluated using agar-well diffusion and broth microdilution method. Bactericidal activity was determined following the European Standard 1276 antibacterial suspension test. Neutralization assay was performed to assess antirespiratory syncytial virus. Safety, stability, and skin permeation of Qi hand gel was investigated. Qi hand sanitizer gel inhibited microorganisms ranging from 99.9% to 99.999% against Enterococcus faecalis, Staphylococcus aureus, methicillin-resistant Staph. aureus, Staph. epidermidis, Staph. pseudintermedius, Staph. saprophyticus, Streptococcus pyogenes, Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Candida albicans. A significant reduction in main human dermatophytes including Microsporum canis, M. gypseum, and Talaromyces marneffei of â¼50% was observed (P < .05). Qi hand sanitizer gel inactivated >99% viral particles entering human laryngeal epidermoid carcinoma cells in a dose-dependent manner. Scanning electron micrographs further illustrated that Qi hand sanitizer gel disrupted microbial cell membrane after 1-min contact time resulting in cell death. Qi hand sanitizer gel delivered emollient compounds through simulated human skin layers and showed no cytotoxicity on fibroblast cells. Moreover, Qi hand sanitizer gel demonstrated stability under extreme conditions.CONCLUSIONS:
Qi hand sanitizer gel was able to inhibit various microorganisms including bacteria, dermatophytes, and virus.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Infecções Estafilocócicas
/
Quercus
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Higienizadores de Mão
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article