Single-cell metabolite profiling enables information-rich classification of lymphocyte types and subtypes.
Chem Commun (Camb)
; 60(4): 392-395, 2024 Jan 04.
Article
em En
| MEDLINE
| ID: mdl-38053454
ABSTRACT
Lymphocytes play crucial roles in the human immune system; however, detailed metabolite characteristics need to be further investigated. Herein, we propose a lymphocyte classification method based on metabolite profiling at the single-cell level. The percentages of different lymphocyte types were calculated with a low margin of error, confirming that the metabolites could serve as a basis for lymphocyte classification. Furthermore, we analyzed the CD4/CD8 ratio in human peripheral blood to verify the feasibility of this method for the classification of lymphocyte subtypes. The proposed method is expected to be a potential tool for the clinical diagnosis of lymphocyte-related diseases.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos
/
Linfócitos T CD8-Positivos
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article