Your browser doesn't support javascript.
loading
Nutrition assessment and MASH severity in children using the Healthy Eating Index.
Jain, Ajay Kumar; Buchannan, Paula; Yates, Katherine P; Belt, Patricia; Schwimmer, Jeffrey B; Rosenthal, Philip; Murray, Karen F; Molleston, Jean P; Scheimann, Ann; Xanthakos, Stavra A; Behling, Cynthia A; Hertel, Paula; Nilson, Jamie; Neuschwander-Tetri, Brent A; Tonascia, James; Vos, Miriam B.
Afiliação
  • Jain AK; Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Saint Louis University, St. Louis, Missouri, USA.
  • Buchannan P; Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Saint Louis University, St. Louis, Missouri, USA.
  • Yates KP; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Belt P; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Schwimmer JB; Department of Pediatrics, Division of Gastroenterology, UC San Diego, La Jolla, California, USA.
  • Rosenthal P; Department of Gastroenterology, Rady Children's Hospital, San Diego, California, USA.
  • Murray KF; Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California, San Francisco Benioff Children's Hospital, San Francisco, California, USA.
  • Molleston JP; Pediatrics Institute, Cleveland Clinic and Cleveland Clinic Children's Hospital, Cleveland, Ohio.
  • Scheimann A; Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Indiana University School of Medicine/Riley Hospital for Children, Indianapolis, Indiana, USA.
  • Xanthakos SA; Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Johns Hopkins University, Baltimore, Maryland, USA.
  • Behling CA; Steatohepatitis Center, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
  • Hertel P; Department of Pediatrics, Division of Gastroenterology, UC San Diego, La Jolla, California, USA.
  • Nilson J; Department of Gastroenterology and Pacific Rim Pathology, San Diego, California, USA.
  • Neuschwander-Tetri BA; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, USA.
  • Tonascia J; Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Saint Louis University, St. Louis, Missouri, USA.
  • Vos MB; Division of Gastroenterology and Hepatology, Saint Louis University, St. Louis, Missouri, USA.
Hepatol Commun ; 7(12)2023 Dec 01.
Article em En | MEDLINE | ID: mdl-38055641
BACKGROUND: Pediatric metabolic-associated fatty liver disease (MAFLD) is a global health problem, with lifestyle modification as its major therapeutic strategy. Rigorous characterization of dietary content on MAFLD in children is lacking. We hypothesized an objectively measured healthier diet would positively modulate MAFLD. METHODS: Diet was assessed using the Nutrition Data System for Research in children enrolled from 10 tertiary clinical centers to determine the Healthy Eating Index (HEI, 0-100) and individual food components. RESULTS: In all, 119 children were included (13.3 ± 2.7 y), 80 (67%) male, 67 (18%) White, and 90 (76%) Hispanic, with an average body mass index Z-score of 2.2 ± 0.5. Diet was classified as low HEI < 47.94 (n = 39), mid HEI ≥ 47.94 and < 58.89 (n = 41), or high HEI ≥ 58.89 (n=39). Children with high HEI (healthier diet) had lower body weight (p = 0.005) and more favorable lipids. Mean serum triglycerides for low, mid, and high HEI were 163, 148, and 120 mg/dL, respectively; p = 0.04 mid versus high, p = 0.01 low versus high. Mean HDL was 38, 41 and 43 mg/dL; p = 0.02 low vs high. Less severe steatosis was noted with added sugar ≤ 10% of calories (p = 0.03). Higher lobular inflammation is associated with a higher percentage of calories from fat (OR (95% CI) = 0.95 (0.91-1.00), p = 0.04). CONCLUSIONS: In children with MAFLD, high HEI is associated with lower body weight and more favorable lipids, while added sugar and fat intake has individual histologic features. Differential consumption of major dietary components may modify both metabolic risk factors and histologic liver injury, highlighting the importance of objective diet assessments in children with MAFLD.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Avaliação Nutricional / Dieta Saudável Limite: Child / Female / Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Avaliação Nutricional / Dieta Saudável Limite: Child / Female / Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article