Veronica linariifolia subsp. dilatata ameliorates LPS-induced acute lung injury by attenuating endothelial cell barrier dysfunction via EGFR/Akt/ZO-1 pathway.

Wu, Huayan; Wu, Longlong; Yu, Wenchao; Gu, Chenming; Li, Yiming; Chen, Kaixian; Zhang, Liuqiang; Qian, Fei

Wu, Huayan; Wu, Longlong; Yu, Wenchao; Gu, Chenming; Li, Yiming; Chen, Kaixian; Zhang, Liuqiang; Qian, Fei.

Afiliação

Wu H; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Wu L; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Yu W; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Gu C; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Li Y; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Chen K; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Zhang L; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: 04100217@163.com.
Qian F; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China. Electronic address: qianfei0517@126.com.

J Ethnopharmacol ; 321: 117545, 2024 Mar 01.

Article em En | MEDLINE | ID: mdl-38056533

Assuntos

Lesão Pulmonar Aguda; Lipopolissacarídeos; Humanos; Masculino; Camundongos; Animais; Lipopolissacarídeos/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Simulação de Acoplamento Molecular; Lesão Pulmonar Aguda/induzido quimicamente; Lesão Pulmonar Aguda/tratamento farmacológico; Lesão Pulmonar Aguda/metabolismo; Pulmão; Células Endoteliais; Citocinas/metabolismo; Edema/metabolismo; Receptores ErbB/metabolismo

Palavras-chave

Acute lung injury; Akt; EGFR; Endothelial barrier dysfunction; Veronica linariifolia subsp. dilatata

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lipopolissacarídeos / Lesão Pulmonar Aguda Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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