Increased glucose metabolism and impaired glutamate transport in human astrocytes are potential early triggers of abnormal extracellular glutamate accumulation in hiPSC-derived models of Alzheimer's disease.

Salcedo, Claudia; Pozo Garcia, Victoria; García-Adán, Bernat; Ameen, Aishat O; Gegelashvili, Georgi; Waagepetersen, Helle S; Freude, Kristine K; Aldana, Blanca I

Salcedo, Claudia; Pozo Garcia, Victoria; García-Adán, Bernat; Ameen, Aishat O; Gegelashvili, Georgi; Waagepetersen, Helle S; Freude, Kristine K; Aldana, Blanca I.

Afiliação

Salcedo C; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Pozo Garcia V; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
García-Adán B; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Ameen AO; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Gegelashvili G; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Waagepetersen HS; Institute of Chemical Biology, Ilia State University, Tbilisi, Georgia.
Freude KK; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Aldana BI; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.

J Neurochem ; 2023 Dec 08.

Article em En | MEDLINE | ID: mdl-38063257