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Novel indolinone-tethered benzothiophenes as anti-tubercular agents against MDR/XDR M. tuberculosis: Design, synthesis, biological evaluation and in vivo pharmacokinetic study.
Eldehna, Wagdy M; Mahmoud, Sally Tarek; Elshnawey, Esraa R; Elsayed, Zainab M; Majrashi, Taghreed A; El-Ashrey, Mohamed K; Rashed, Mahmoud; Hemeda, Loah R; Shoun, Aly A; Elkaeed, Eslam B; El Hassab, Mahmoud A; Abdel-Aziz, Marwa M; Shahin, Mai I.
Afiliação
  • Eldehna WM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt; Scientific Research and Innovation Support Unit, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt. Electronic address: wagdy2000@gmail.com.
  • Mahmoud ST; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr Elini St., Cairo, 11562, Egypt.
  • Elshnawey ER; Scientific Research and Innovation Support Unit, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.
  • Elsayed ZM; Scientific Research and Innovation Support Unit, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.
  • Majrashi TA; Department of Pharmacognosy, College of Pharmacy, King Khalid University, Asir 61421, Saudi Arabia.
  • El-Ashrey MK; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr Elini St., Cairo, 11562, Egypt; Medicinal Chemistry Department, Faculty of Pharmacy, King Salman International University, Ras-Sedr, South Sinai, 46612, Egypt.
  • Rashed M; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
  • Hemeda LR; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.
  • Shoun AA; Microbiology and Immunology Department, Faculty of Pharmacy, El Saleheya El Gadida University, El Saleheya El Gadida, 44813, Egypt.
  • Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh 13713, Saudi Arabia.
  • El Hassab MA; Medicinal Chemistry Department, Faculty of Pharmacy, King Salman International University, Ras-Sedr, South Sinai, 46612, Egypt.
  • Abdel-Aziz MM; The Regional Center for Mycology and Biotechnology, Al-Azhar University, Cairo 11651, Egypt.
  • Shahin MI; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, Egypt.
Bioorg Chem ; 143: 107009, 2024 Feb.
Article em En | MEDLINE | ID: mdl-38070474
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiofenos / Tuberculose Resistente a Múltiplos Medicamentos / Tuberculose Extensivamente Resistente a Medicamentos / Mycobacterium tuberculosis Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiofenos / Tuberculose Resistente a Múltiplos Medicamentos / Tuberculose Extensivamente Resistente a Medicamentos / Mycobacterium tuberculosis Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article