mRNA accessibility within mRNPs as a determinant of gene expression.
Trends Biochem Sci
; 49(3): 199-207, 2024 03.
Article
em En
| MEDLINE
| ID: mdl-38071089
ABSTRACT
Gene expression is a complex process requiring many control mechanisms to achieve a desired phenotype. DNA accessibility within chromatin is well established as an important determinant of gene expression. By contrast, while mRNA also associates with a complement of proteins, the exact nature of messenger ribonucleoprotein (mRNP) packaging and its functional relevance is not as clear. Recent reports indicate that exon junction complex (EJC)-mediated mRNP packaging renders exon junction-proximal regions inaccessible for m6A methylation, and that EJCs reside within the inaccessible interior of globular transcription and export (TREX) complex-associated nuclear mRNPs. We propose that 'mRNA accessibility' within mRNPs is an important determinant of gene expression that may modulate the specificity of a broad array of regulatory processes including but not limited to m6A methylation.
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Base de dados:
MEDLINE
Assunto principal:
Ribonucleoproteínas
/
Núcleo Celular
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article