Correlation between Serum MMP-2/-16 Levels and Inflammation in Patients with Deep Vein Thrombosis.
Clin Lab
; 69(12)2023 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-38084687
ABSTRACT
BACKGROUND:
The aim of the study was to clarify the correlation between serum MMP-2/-16 and inflammation in patients with deep venous thrombosis (DVT).METHODS:
Sixty DVT patients and 60 healthy people who underwent health examinations were collected. Serum MMP-2/-16, IL-6/-8, and TNF-α were determined by ELISA. MMP-2/-16 protein levels were detected by western blot, and IL-6/-8 and TNF-α by RT-qPCR. Correlation analysis was performed on MMP-2/-16xdd, IL-6/-8, and TNF-α in DVT patients.RESULTS:
MMP-2/-16, IL-6/-8, and TNF-α in DVT patients after treatment were lower than before treatment. Serum IL-6/-8 and TNF-α levels in DVT patients were both positively correlated with MMP-2/-16 levels.CONCLUSIONS:
MMP-2/-16 and inflammatory factors are related to DVT development, and IL-6/-8 and TNF-α are positively correlated with MMP-2/-16.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Interleucina-6
/
Trombose Venosa
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article