Random mutagenesis as a tool for industrial strain improvement for enhanced production of antibiotics: a review.
Mol Biol Rep
; 51(1): 19, 2023 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-38100064
ABSTRACT
Secondary metabolites are produced by microbes in minimal quantities in the natural environment out of necessity. However, in the pharmaceutical industry, their overproduction becomes essential. To achieve higher yields, genetic modifications are employed to create strains that surpass the productivity of the initially isolated strains. While rational screening and genetic engineering have emerged as valuable practices in recent years, the cost-effective technique of mutagenesis and selection, known as "random screening," remains a preferred method for efficient short-term strain development. This review aims to comprehensively explore all aspects of strain improvement, focusing on why random mutagenesis continues to be widely adopted.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Meio Ambiente
/
Antibacterianos
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article