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Management of radiation-induced oral mucositis in head and neck cancer patients: a real-life survey among 25 Italian radiation oncology centers.
Bergamaschi, Luca; Vincini, Maria Giulia; Zaffaroni, Mattia; Pepa, Matteo; Angelicone, Ilaria; Astone, Antonio; Bergamini, Cristiana; Buonopane, Sergio; Conte, Mario; De Rosa, Nicola; Deantoni, Chiara; Dell'Oca, Italo; Di Gennaro, Davide; Di Muzio, Nadia; Osti, Mattia Falchetto; Federico, Manuela; Ferini, Gianluca; Franzese, Ciro; Gatti, Marco; Grillo, Antonietta; Iorio, Vincenzo; Manzo, Roberto; Marmiroli, Luca; Martin, Giuseppe; Mazzuca, Federica; Molinaro, Maria Angela; Muto, Matteo; Pacelli, Roberto; Pepe, Alfonsina; Perillo, Annarita; Russo, Donatella; Salerno, Francesca; Spadaro, Pietro; Viola, Anna; Iorio, Giuseppe Carlo; Muto, Paolo; Ricardi, Umberto; Alterio, Daniela.
Afiliação
  • Bergamaschi L; Division of Radiation Oncology, European Institute of Oncology IRCCS, 20141, Milan, Italy.
  • Vincini MG; Division of Radiation Oncology, European Institute of Oncology IRCCS, 20141, Milan, Italy. mariagiulia.vincini@ieo.it.
  • Zaffaroni M; Division of Radiation Oncology, European Institute of Oncology IRCCS, 20141, Milan, Italy.
  • Pepa M; Division of Radiation Oncology, European Institute of Oncology IRCCS, 20141, Milan, Italy.
  • Angelicone I; Radiotherapy Department, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
  • Astone A; Division of Medical Oncology, Fatebenefratelli San Pietro Hospital, 00189, Rome, Italy.
  • Bergamini C; Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
  • Buonopane S; Radiation Oncology Unit, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, Naples, Italy.
  • Conte M; Fondazione Muto Onlus, Casavatore, Naples, Italy.
  • De Rosa N; Centro Aktis Diagnostica e Terapia, Marano, Naples, Italy.
  • Deantoni C; Radiotherapy Department, IRCCS San Raffaele Scientific Institute, Vita Salute S. Raffaele University, Milan, Italy.
  • Dell'Oca I; Radiotherapy Department, IRCCS San Raffaele Scientific Institute, Vita Salute S. Raffaele University, Milan, Italy.
  • Di Gennaro D; Azienda Ospedaliera Universitaria Ruggi D'Aragona, Salerno, Italy.
  • Di Muzio N; Radiotherapy Department, IRCCS San Raffaele Scientific Institute, Vita Salute S. Raffaele University, Milan, Italy.
  • Osti MF; Radiotherapy Department, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
  • Federico M; Casa di cura Macchiarella, U.O. Radioterapia Oncologica, Palermo, Italy.
  • Ferini G; Radiation Oncology Unit, REM Radioterapia, Viagrande, Italy.
  • Franzese C; Department of Radiotherapy and Radiosurgery, Humanitas Clinical and Research Center-IRCCS, Rozzano, Milan, Italy.
  • Gatti M; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
  • Grillo A; Radiotherapy Unit, Candiolo Cancer Institute, FPO-IRCCS, Torino, Italy.
  • Iorio V; Radiation Oncology Unit, Azienda Ospedaliero-Universitaria Policlinico, Bari, Italy.
  • Manzo R; Fondazione Muto Onlus, Casavatore, Naples, Italy.
  • Marmiroli L; Radiation Oncology Unit, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, Naples, Italy.
  • Martin G; U.O. Radioterapia, Ospedale Fatebenefratelli S. Giovanni Calibita, Isola Tiberina, 00186, Rome, Italy.
  • Mazzuca F; Centro Radiologico Vega, Caserta, Italy.
  • Molinaro MA; Radiotherapy Department, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
  • Muto M; U.O. Radioterapia A.O. Pugliese Ciaccio di Catanzaro, Catanzaro, Italy.
  • Pacelli R; Department of Onco-Hematological Diseases, U.O.C. Radiotherapy-Azienda Ospedaliera San Giuseppe Moscati-(AV), 83100, Avellino, Italy.
  • Pepe A; Department of Advanced Biomedical Sciences, Federico II University School of Medicine, Naples, Italy.
  • Perillo A; Radioterapia Emicenter, Naples, Italy.
  • Russo D; Centro Aktis Diagnostica e Terapia, Marano, Naples, Italy.
  • Salerno F; Department of Radiation Oncology, San Pio Hospital, Benevento, Italia.
  • Spadaro P; Radiotherapy Unit, Ospedale "Vito Fazzi,", Lecce, Italy.
  • Viola A; UOC Radioterapia, ASL Roma1, Borgo S. Spirito, Rome, Italy.
  • Iorio GC; U.O. di Oncologia ed Ematologia, Casa di Cura Villa Salus, Messina, Italy.
  • Muto P; Fondazione IOM, Viagrande, Catania, Italy.
  • Ricardi U; Department of Oncology, Radiation Oncology, University of Turin, Turin, Italy.
  • Alterio D; Radiation Oncology Unit, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, Naples, Italy.
Support Care Cancer ; 32(1): 38, 2023 Dec 19.
Article em En | MEDLINE | ID: mdl-38110572
ABSTRACT

AIM:

Radiation-induced oral mucositis (RIOM) is the most frequent side effect in head and neck cancer (HNC) patients treated with curative radiotherapy (RT). A standardized strategy for preventing and treating RIOM has not been defined. Aim of this study was to perform a real-life survey on RIOM management among Italian RT centers.

METHODS:

A 40-question survey was administered to 25 radiation oncologists working in 25 different RT centers across Italy.

RESULTS:

A total of 1554 HNC patients have been treated in the participating centers in 2021, the majority (median across the centers 91%) with curative intent. Median treatment time was 41 days, with a mean percentage of interruption due to toxicity of 14.5%. Eighty percent of responders provide written oral cavity hygiene recommendations. Regarding RIOM prevention, sodium bicarbonate mouthwashes, oral mucosa barrier agents, and hyaluronic acid-based mouthwashes were the most frequent topic agents used. Regarding RIOM treatment, 14 (56%) centers relied on literature evidence, while internal guidelines were available in 13 centers (44%). Grade (G)1 mucositis is mostly treated with sodium bicarbonate mouthwashes, oral mucosa barrier agents, and steroids, while hyaluronic acid-based agents, local anesthetics, and benzydamine were the most used in mucositis G2/G3. Steroids, painkillers, and anti-inflammatory drugs were the most frequent systemic agents used independently from the RIOM severity.

CONCLUSION:

Great variety of strategies exist among Italian centers in RIOM management for HNC patients. Whether different strategies could impact patients' compliance and overall treatment time of the radiation course is still unclear and needs further investigation.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lesões por Radiação / Estomatite / Radioterapia (Especialidade) / Mucosite / Neoplasias de Cabeça e Pescoço Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lesões por Radiação / Estomatite / Radioterapia (Especialidade) / Mucosite / Neoplasias de Cabeça e Pescoço Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article