Caffeine and cortical excitability, as measured with paired-pulse transcranial magnetic stimulation.
Muscle Nerve
; 69(2): 206-212, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-38124685
ABSTRACT
INTRODUCTION/AIMS:
The transcranial magnetic stimulation tests of short-interval intracortical inhibition (SICI) by both conventional amplitude measurements (A-SICI) and threshold-tracking (T-SICI) are important methods to investigate intracortical inhibitory circuits, and T-SICI has been proposed to aid the diagnosis of amyotrophic lateral sclerosis. Beverages containing caffeine are widely consumed, and caffeine has been reported to affect cortical excitability. The aim of this study was to determine whether these SICI tests are affected by caffeine.METHODS:
Twenty-four healthy subjects (13 females, 11 males, aged from 19 to 31, mean 26.2 ± 2.4 years) were studied in a single fixed-dose randomized double-blind placebo-controlled cross-over trial of 200 mg caffeine or placebo ingested as chewing gum. A-SICI and T-SICI, using parallel tracking (T-SICIp), were performed before and after chewing gum.RESULTS:
There was no significant change in SICI parameters after placebo in A-SICI (p > .10) or T-SICIp (p > .30), and no significant effect of caffeine was found on A-SICI (p > .10) or T-SICIp (p > .50) for any of the interstimulus intervals.DISCUSSION:
There is no need for caffeine abstention before measurements of SICI by either the T-SICI or A-SICI measurements.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Excitabilidade Cortical
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Córtex Motor
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article