Inescapable foot shock induces a PTSD-like phenotype and negatively impacts adult murine bone.
Dis Model Mech
; 17(1)2024 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-38131122
ABSTRACT
Post-traumatic stress disorder (PTSD) is associated with osteopenia, osteoporosis and increased fracture risk in the clinical population. Yet, the development of preclinical models to study PTSD-induced bone loss remains limited. In this study, we present a previously unreported model of PTSD in adult female C57BL/6 mice, by employing inescapable foot shock and social isolation, that demonstrates high face and construct validity. A subset of mice exposed to this paradigm (i.e. PTSD mice) display long-term alterations in behavioral and inflammatory indices. Using three-dimensional morphometric calculations, cyclic reference point indentation (cRPI) testing and histological analyses, we find that PTSD mice exhibit loss of trabecular bone, altered bone material quality, and aberrant changes in bone tissue architecture and cellular activity. This adult murine model of PTSD exhibits clinically relevant changes in bone physiology and provides a valuable tool for investigating the cellular and molecular mechanisms underlying PTSD-induced bone loss.
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Base de dados:
MEDLINE
Assunto principal:
Transtornos de Estresse Pós-Traumáticos
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article