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Latent Tuberculosis Infection and COVID-19: Analysis of a Cohort of Patients from Careggi University Hospital (Florence, Italy).
Mariotti, Francesca; Sponchiado, Francesco; Lagi, Filippo; Moroni, Chiara; Paggi, Riccardo; Kiros, Seble Tekle; Miele, Vittorio; Bartoloni, Alessandro; Mencarini, Jessica.
Afiliação
  • Mariotti F; Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.
  • Sponchiado F; Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.
  • Lagi F; Infectious and Tropical Diseases Unit, Careggi University Hospital, 50134 Florence, Italy.
  • Moroni C; Emergency Radiology Unit, Careggi University Hospital, 50134 Florence, Italy.
  • Paggi R; Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.
  • Kiros ST; Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.
  • Miele V; Emergency Radiology Unit, Careggi University Hospital, 50134 Florence, Italy.
  • Bartoloni A; Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.
  • Mencarini J; Infectious and Tropical Diseases Unit, Careggi University Hospital, 50134 Florence, Italy.
  • The Cocora Working Group; Infectious and Tropical Diseases Unit, Careggi University Hospital, 50134 Florence, Italy.
Infect Dis Rep ; 15(6): 758-765, 2023 Dec 10.
Article em En | MEDLINE | ID: mdl-38131881
ABSTRACT
Data regarding the relationship between coronavirus disease (COVID-19) and active or latent tuberculosis (TB) are discordant. We conducted a retrospective study examining the impact of latent tuberculosis infection (LTBI) on the clinical progression of COVID-19 patients. We selected 213 patients admitted with COVID-19 in a tertiary-level Italian hospital (February-December 2020), who underwent a QuantiFERON-TB test (QFT) and/or chest radiological exam. The population was divided into three groups (i) QFT negative and without radiological TB sequelae (Neg); (ii) QFT positive and without radiological TB sequelae (Pos); (iii) radiological TB sequelae regardless of QFT result (Seq). In-hospital mortality and oro-tracheal intubation (OTI) showed significantly higher results in the Seq group (Seq 50% vs. Pos 13.3% vs. Neg 9.3%, p < 0.001; Seq 16.7% vs. Pos 6.7% vs. Neg 4.9%, p = 0.045). Considering the Pos and Seq groups' patients as the population with defined LTBI, in-hospital mortality (20/51, 39.2%) and OTI risk (7/51, 13.7%) were statistically higher with respect to patients without LTBI (in-hospital mortality 15/162, 9.3%, p < 0.001; OTI risk 8/162, 4.9%, p = 0.023), respectively. Multivariate analysis showed that radiological sequelae and the Charlson Comorbidity Index (CCI) were significantly associated with higher mortality rate; despite the higher CCI of Seq population, we cannot exclude the correlation between COVID-19 in-hospital mortality and the presence of radiological TB sequelae.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article