Determination and verification of reference intervals of serum immunoglobulin G at birth.
Ann Clin Biochem
; 61(4): 319-326, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38135290
ABSTRACT
BACKGROUND:
To accurately assess hypogammaglobulinemia at birth, it is essential to determine the reference intervals of serum immunoglobulin (IgG) levels in newborns. In the present study, we determined the gestational age (GA)-/birth weight (BW)-dependent percentile-based reference intervals of serum IgG levels and converted them into simple formulas for practical use.METHODS:
Serum IgG levels were measured in cord blood from 2902 newborns delivered at 22 to 41 weeks of GA or 264 to 4642 g of BW after exclusion of those with congenital disorders. Linear regression analysis was used to correlate GA and UC-IgG levels and BW and UC-IgG levels. After calculation of the percentile values of UC-IgG levels for each GA or BW, the distributions were approximated by the least-squares method. Fitness was evaluated by the coefficient of determination (R2).RESULTS:
Significant positive correlations were found both between GA and UC-IgG levels (rs = 0.790, P < 0.001) and BW and UC-IgG levels (rs = 0.626, P < 0.001). The distribution of the 5%ile of UC-IgG levels (Y) by GA or BW (X) was approximated as a straight line (Y = 37.5 *X - 775.8; Y = 0.161 *X + 95.34, respectively). The fitness was stronger in the GA-derived formula than the BW-derived formula (R2 = 0.973 vs 0.913).CONCLUSIONS:
We established GA-/BW-dependent reference percentile-based intervals for serum IgG levels using cord blood from 2902 newborns without congenital disorders. Using GA-dependent reference intervals may be useful for assessing hypogammaglobulinemia at birth.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Peso ao Nascer
/
Imunoglobulina G
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Idade Gestacional
/
Sangue Fetal
Limite:
Female
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Humans
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Male
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Newborn
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article