Synthesis of Six-Membered N-Heterocyclic Carbene Precursors Based on Camphor.
Molecules
; 28(24)2023 Dec 06.
Article
em En
| MEDLINE
| ID: mdl-38138463
ABSTRACT
The endo- and exo-N-heterocyclic carbene precursors based on camphor were prepared diastereoselectively in five synthetic steps starting from (1S)-(+)-ketopinic acid. The obtained N-heterocyclic carbene precursors were investigated in an asymmetric benzoin reaction. All new compounds were fully characterized, and the absolute configurations were determined via X-ray diffraction and NOESY measurements.
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MEDLINE
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En
Ano de publicação:
2023
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Article