Antibiotics and Antibiotic Resistance-Mur Ligases as an Antibacterial Target.
Molecules
; 28(24)2023 Dec 13.
Article
em En
| MEDLINE
| ID: mdl-38138566
ABSTRACT
The emergence of Multidrug Resistance (MDR) strains of bacteria has accelerated the search for new antibacterials. The specific bacterial peptidoglycan biosynthetic pathway represents opportunities for the development of novel antibacterial agents. Among the enzymes involved, Mur ligases, described herein, and especially the amide ligases MurC-F are key targets for the discovery of multi-inhibitors, as they share common active sites and structural features.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ligases
/
Antibacterianos
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article