Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic challenges.
Front Med
; 17(6): 1135-1169, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-38151666
ABSTRACT
Pancreatic cancer, notorious for its late diagnosis and aggressive progression, poses a substantial challenge owing to scarce treatment alternatives. This review endeavors to furnish a holistic insight into pancreatic cancer, encompassing its epidemiology, genomic characterization, risk factors, diagnosis, therapeutic strategies, and treatment resistance mechanisms. We delve into identifying risk factors, including genetic predisposition and environmental exposures, and explore recent research advancements in precursor lesions and molecular subtypes of pancreatic cancer. Additionally, we highlight the development and application of multi-omics approaches in pancreatic cancer research and discuss the latest combinations of pancreatic cancer biomarkers and their efficacy. We also dissect the primary mechanisms underlying treatment resistance in this malignancy, illustrating the latest therapeutic options and advancements in the field. Conclusively, we accentuate the urgent demand for more extensive research to enhance the prognosis for pancreatic cancer patients.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article