Possible association between ß-blocker use and a risk of intracranial aneurysm rupture.
Pol Arch Intern Med
; 134(2)2024 02 28.
Article
em En
| MEDLINE
| ID: mdl-38164646
ABSTRACT
INTRODUCTION:
Aneurysmal subarachnoid hemorrhage is a devastating type of stroke, associated with high mortality and morbidity. One of modifiable risk factors of aneurysm rupture is hypertension, however, it is still not clear whether any particular antihypertensive drugs play a significant role in the prevention of aneurysm rupture.OBJECTIVES:
We decided to investigate whether there is any association between acetylsalicylic acid, α-blockers, ßblockers, angiotensinconverting enzyme inhibitors, angiotensin II receptor blockers, calcium channel blockers, diuretics, statins, and anticoagulants and a risk of intracranial aneurysm rupture. PATIENTS ANDMETHODS:
We retrospectively analyzed 334 patients with ruptured and unruptured intracranial aneurysm. Based on logistic regression models, we obtained unadjusted and adjusted odds ratios (ORs) of subarachnoid hemorrhage associated with the use of vasoactive medications and with indices of tortuosity.RESULTS:
We found that ßblocker intake was significantly related to higher tortuosity of the cerebral arteries. Also, the intake of ßblockers (OR, 0.41; 95% CI, 0.21-0.77; P = 0.01) and statins (OR, 0.23; 95% CI, 0.05-0.68; P = 0.01) significantly decreased the risk of aneurysm rupture, a result driven by a decreased rupture risk of anterior circulation aneurysms. No such association was found for the posterior part of the cerebral circulation.CONCLUSIONS:
Aneurysm located in the anterior cerebral circulation might be less likely to rupture if patients receive ßblockers or statins.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hemorragia Subaracnóidea
/
Aneurisma Intracraniano
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Aneurisma Roto
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Inibidores de Hidroximetilglutaril-CoA Redutases
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article