Antizyme inhibitor family: biological and translational research implications.
Cell Commun Signal
; 22(1): 11, 2024 01 02.
Article
em En
| MEDLINE
| ID: mdl-38169396
ABSTRACT
Metabolism of polyamines is of critical importance to physiological processes. Ornithine decarboxylase (ODC) antizyme inhibitors (AZINs) are capable of interacting with antizymes (AZs), thereby releasing ODC from ODC-AZs complex, and promote polyamine biosynthesis. AZINs regulate reproduction, embryonic development, fibrogenesis and tumorigenesis through polyamine and other signaling pathways. Dysregulation of AZINs has involved in multiple human diseases, especially malignant tumors. Adenosine-to-inosine (A-to-I) RNA editing is the most common type of post-transcriptional nucleotide modification in humans. Additionally, the high frequencies of RNA-edited AZIN1 in human cancers correlates with increase of cancer cell proliferation, enhancement of cancer cell stemness, and promotion of tumor angiogenesis. In this review, we summarize the current knowledge on the various contribution of AZINs related with potential cancer promotion, cancer stemness, microenvironment and RNA modification, especially underlying molecular mechanisms, and furthermore explored its promising implication for cancer diagnosis and treatment.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ornitina Descarboxilase
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Pesquisa Translacional Biomédica
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article