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18F-THK5351 Positron Emission Tomography Clearly Depicted Progressive Multifocal Leukoencephalopathy after Mantle Cell Lymphoma Treatment.
Chiba, Yuta; Kawakita, Rie; Mitamura, Katsuya; Takahashi, Kenta; Suzuki, Tadaki; Nakamichi, Kazuo; Suzuki, Kenta; Morishita, Asahiro; Kobara, Hideki; Deguchi, Kazushi; Masaki, Tsutomu.
Afiliação
  • Chiba Y; Department of Gastroenterology and Neurology, Graduate School of Medicine and Faculty of Medicine, Kagawa University, Japan.
  • Kawakita R; Department of Gastroenterology and Neurology, Graduate School of Medicine and Faculty of Medicine, Kagawa University, Japan.
  • Mitamura K; Department of Radiology, Graduate School of Medicine and Faculty of Medicine, Kagawa University, Japan.
  • Takahashi K; Department of Pathology, National Institute of Infectious Diseases, Japan.
  • Suzuki T; Department of Pathology, National Institute of Infectious Diseases, Japan.
  • Nakamichi K; Department of Virology 1, National Institute of Infectious Diseases, Japan.
  • Suzuki K; Department of Neurosurgery, Graduate School of Medicine and Faculty of Medicine, Kagawa University, Japan.
  • Morishita A; Department of Gastroenterology and Neurology, Graduate School of Medicine and Faculty of Medicine, Kagawa University, Japan.
  • Kobara H; Department of Gastroenterology and Neurology, Graduate School of Medicine and Faculty of Medicine, Kagawa University, Japan.
  • Deguchi K; Department of Gastroenterology and Neurology, Graduate School of Medicine and Faculty of Medicine, Kagawa University, Japan.
  • Masaki T; Department of Gastroenterology and Neurology, Graduate School of Medicine and Faculty of Medicine, Kagawa University, Japan.
Intern Med ; 63(16): 2325-2329, 2024 Aug 15.
Article em En | MEDLINE | ID: mdl-38171868
ABSTRACT
An 84-year-old Japanese woman presented with left hemiplegia 8 months after completing chemotherapy for mantle cell lymphoma. Brain magnetic resonance imaging (MRI) revealed a hyperintense lesion extending from the right parietal lobe to the left parietal lobe. Compared with these MRI results, 18F-THK5351 PET revealed more extensive accumulation. A brain biopsy showed progressive multifocal leukoencephalopathy (PML). Immunohistochemistry and John Cunningham virus (JCV) DNA-polymerase chain reaction indicated JCV infection. Therefore, a diagnosis of PML was made. 18F-THK5351 PET, indicative of activated astrocytes, clearly depicted PML lesions composed of reactive and atypical astrocytes. 18F-THK5351 PET may capture fresh progressive PML lesions better than MRI.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucoencefalopatia Multifocal Progressiva / Linfoma de Célula do Manto / Tomografia por Emissão de Pósitrons Limite: Aged80 / Female / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucoencefalopatia Multifocal Progressiva / Linfoma de Célula do Manto / Tomografia por Emissão de Pósitrons Limite: Aged80 / Female / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article