Associations of liver function with plasma biomarkers for Alzheimer's Disease.
Neurol Sci
; 45(6): 2625-2631, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38177970
ABSTRACT
BACKGROUND:
Blood-based biomarkers for Alzheimer's disease (AD) are promising to be used in clinical settings. The liver is an important degradation organ of the body. Whether liver function affects the levels of AD biomarkers needs to be studied.OBJECTIVE:
To investigate the associations between liver function and the plasma levels of AD biomarkers.METHODS:
We conducted an ADNI cohort-based cross-sectional study. Thirteen liver function markers commonly used in clinical settings were analyzed total protein (TP), albumin (AL), globulin (GL), AL/GL ratio (A/G), total bilirubin (TB), direct bilirubin (DB), indirect bilirubin (IB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), AST/ALT ratio, alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and γ-glutamyltransferase (GGT). Liquid chromatography-tandem mass spectrometry was used to detect the plasma Aß42 and Aß40 concentrations. Single Molecule array technique was used to measure the plasma p-tau181 and NfL concentrations. We used linear regression models to analyze the associations between liver function markers and the levels of AD plasma biomarkers.RESULTS:
ALP was positively associated with the levels of plasma Aß42 (ß = 0.16, P = 0.018) and Aß40 (ß = 0.21, P = 0.004). LDH was positively associated with the levels of plasma p-tau181 (ß = 0.09, P = 0.022). While NfL was correlated with multiple liver function markers, including AL, A/G, ALT, AST/ALT, and LDH.CONCLUSION:
Liver function was associated with the plasma levels of AD biomarkers. It needs to consider the potential influence of liver function on the reference ranges and the interpretation of results for AD biomarkers before clinical use.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Biomarcadores
/
Peptídeos beta-Amiloides
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Doença de Alzheimer
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Aged
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Aged80
/
Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article