TMSOTf-Catalyzed Reactions of N-Arylynamides with Sulfilimines To Construct 2-Aminoindoles and α-Arylated Amidines.
J Org Chem
; 89(2): 1193-1198, 2024 Jan 19.
Article
em En
| MEDLINE
| ID: mdl-38178688
ABSTRACT
Here, we disclose an efficient TMSOTf-catalyzed C-H annulation of aryl-terminated N-arylynamides with sulfilimines, leading to the practical assembly of various valuable 2-aminoindoles in generally moderate to excellent yields with a broad range of functional groups, while nonaryl terminated N-arylynamides undergo TMSOTf-catalyzed aminative arylation with sulfilimines providing α-arylated amidines.
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Base de dados:
MEDLINE
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En
Ano de publicação:
2024
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Article