Copper-Catalyzed Asymmetric Synthesis of Silicon-Stereogenic Benzoxasiloles.
Angew Chem Int Ed Engl
; 63(7): e202317973, 2024 Feb 12.
Article
em En
| MEDLINE
| ID: mdl-38179840
ABSTRACT
A Cu-catalyzed asymmetric synthesis of silicon-stereogenic benzoxasiloles has been realized via intramolecular Si-O coupling of [2-(hydroxymethyl)phenyl]silanes. Cu(I)/difluorphos is found to be an efficient catalytic system for enantioselective Si-C bond cleavage and Si-O bond formation. In addition, kinetic resolution of racemic substituted [2-(hydroxymethyl)phenyl]silanes using Cu(I)/ PyrOx (pyridine-oxazoline ligands) as the catalytic system is developed to afford carbon- and silicon-stereogenic benzoxasiloles. Ring-opening reactions of chiral benzoxasiloles with organolithiums and Grignard reagents yield various enantioenriched functionalized tetraorganosilanes.
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MEDLINE
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En
Ano de publicação:
2024
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Article