Serum phospholipid fatty acids are associated with bone mass in healthy 4-years-old children.
Prostaglandins Leukot Essent Fatty Acids
; 200: 102606, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-38181601
ABSTRACT
BACKGROUND:
Fatty acids are involved in bone development but knowledge in children is limited. The aim of this study was to investigate bone mass and mineral density in healthy preschool children in relation to fatty acids. MATERIAL ANDMETHODS:
In 111 healthy 4-yrs-old children (20 % overweight) bone was analysed by dual X-ray absorptiometry and serum phospholipid fatty acid by gas chromatography. Fat intake was calculated from 7 days self-reported dietary records and food frequency questionnaire.RESULTS:
Total bone mass content (BMC) and mineral density (BMD) differed by sex in normal weight, but not in overweight children showing generally higher bone mass density than children with normal weight. Linoleic acid intake was strongly correlated to BMC and femoral BMD in normal weight children. Serum concentration of docosahexaenoic acid correlated positively to BMD in all children (p = 0.01), but linoleic and arachidonic acids, and monounsaturated fatty acids showed diverging associations with bone in normal weight and overweight children.CONCLUSION:
Serum phospholipid DHA was associated with bone density. Other fatty acids associations to bone sites differed in overweight children, analogue to the pattern in healthy 8-yrs-old.The finding need to be confirmed longitudinally and in a larger group of overweight individuals.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Densidade Óssea
/
Ácidos Graxos
Tipo de estudo:
Risk_factors_studies
Limite:
Child, preschool
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Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article