Regulators of necroinflammation in acute kidney injury.
Kidney Int
; 105(1): 22-25, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-38182296
ABSTRACT
Interleukin (IL)-22 is unique among the ILs as it elicits direct effects on kidney epithelia and regulates cell survival in a context-dependent manner. Studies published in Kidney International and other journals demonstrate opposing roles of IL-22 (e.g., in models of acute kidney injury). In the early necroinflammation phase of acute kidney injury, IL-22 promotes tubular cell death, whereas it enhances the proliferation and regeneration of epithelial barrier function in the healing phase of injured tubules.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Injúria Renal Aguda
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article