Tumor progression in tympanojugular paragangliomas: the role of radiotherapy and wait and scan.
Eur Arch Otorhinolaryngol
; 281(6): 2779-2789, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38184495
ABSTRACT
INTRODUCTION:
Tympanojugular paragangliomas (TJ PGLs) are rare tumors characterized by bone infiltration and erosion and a close relationship with critical structures, such as cranial nerves and internal carotid artery. For these reasons, their management represents a tough challenge. Since the fifties, radio-therapy (RT) has been proposed as an alternative treatment aimed at avoiding tumor progression. However, the indolent nature of the tumor, characterized by slow growth, is a crucial factor that needs to be considered before offering radiation.METHODS:
This study aims to examine tumor progression in RT patients through a systematic review of the literature and in TJ PGL patients who underwent solely wait and scan at our department.RESULTS:
The rate of tumor progression in the RT group was 8.9%, while in the wait and scan cohort was 12.9%. This data suggests the innate slow growth of PGLs. However, it is not possible to draw certain conclusions because of the wide heterogeneity of the studies.CONCLUSION:
When complete surgical excision of TJ PGLs is not feasible, appropriate counseling and patient selection, including comprehensive tumor classification, should be performed before proposing RT to control tumor progression, since wait and scan may represent a reasonable option in selected cases.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Progressão da Doença
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Tumor do Glomo Jugular
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article