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Acute Ischemic Stroke Thrombus Composition.
Vandelanotte, Sarah; De Meyer, Simon F.
Afiliação
  • Vandelanotte S; Laboratory for Thrombosis Research, KU Leuven Kulak, Kortrijk, Belgium.
  • De Meyer SF; Laboratory for Thrombosis Research, KU Leuven Kulak, Kortrijk, Belgium. Electronic address: simon.demeyer@kuleuven.be.
Neuroscience ; 550: 11-20, 2024 Jul 09.
Article em En | MEDLINE | ID: mdl-38185279
ABSTRACT
Ischemic stroke is caused by a thrombus blocking one or multiple arteries in the brain, resulting in irreversible damage in the associated brain tissue. The aim of therapy is to restore the blood flow as fast as possible. Two recanalization strategies are currently available pharmacological thrombolysis using recombinant tissue plasminogen activator (rt-PA) and mechanical removal of the thrombus. Despite recent advancements, achieving efficient recanalization remains a challenge. The precise causes of therapy failure are not fully understood but thrombus composition is likely a key factor in successful recanalization. This review explores acute ischemic stroke thrombus composition, its recently identified components, and how it affects stroke treatment. It also discusses how new insights could enhance current recanalization strategies for ischemic stroke patients.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: AVC Isquêmico Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: AVC Isquêmico Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article