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Population genomics of post-glacial western Eurasia.
Allentoft, Morten E; Sikora, Martin; Refoyo-Martínez, Alba; Irving-Pease, Evan K; Fischer, Anders; Barrie, William; Ingason, Andrés; Stenderup, Jesper; Sjögren, Karl-Göran; Pearson, Alice; Sousa da Mota, Bárbara; Schulz Paulsson, Bettina; Halgren, Alma; Macleod, Ruairidh; Jørkov, Marie Louise Schjellerup; Demeter, Fabrice; Sørensen, Lasse; Nielsen, Poul Otto; Henriksen, Rasmus A; Vimala, Tharsika; McColl, Hugh; Margaryan, Ashot; Ilardo, Melissa; Vaughn, Andrew; Fischer Mortensen, Morten; Nielsen, Anne Birgitte; Ulfeldt Hede, Mikkel; Johannsen, Niels Nørkjær; Rasmussen, Peter; Vinner, Lasse; Renaud, Gabriel; Stern, Aaron; Jensen, Theis Zetner Trolle; Scorrano, Gabriele; Schroeder, Hannes; Lysdahl, Per; Ramsøe, Abigail Daisy; Skorobogatov, Andrei; Schork, Andrew Joseph; Rosengren, Anders; Ruter, Anthony; Outram, Alan; Timoshenko, Aleksey A; Buzhilova, Alexandra; Coppa, Alfredo; Zubova, Alisa; Silva, Ana Maria; Hansen, Anders J; Gromov, Andrey; Logvin, Andrey.
Afiliação
  • Allentoft ME; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark. morten.allentoft@curtin.edu.au.
  • Sikora M; Trace and Environmental DNA (TrEnD) Laboratory, School of Molecular and Life Sciences, Curtin University, Perth, Western Australia, Australia. morten.allentoft@curtin.edu.au.
  • Refoyo-Martínez A; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark. martin.sikora@sund.ku.dk.
  • Irving-Pease EK; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
  • Fischer A; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
  • Barrie W; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
  • Ingason A; Department of Historical Studies, University of Gothenburg, Gothenburg, Sweden.
  • Stenderup J; Sealand Archaeology, Kalundborg, Denmark.
  • Sjögren KG; GeoGenetics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
  • Pearson A; Department of Genetics, University of Cambridge, Cambridge, UK.
  • Sousa da Mota B; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
  • Schulz Paulsson B; Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Roskilde, Denmark.
  • Halgren A; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
  • Macleod R; Department of Historical Studies, University of Gothenburg, Gothenburg, Sweden.
  • Jørkov MLS; Department of Genetics, University of Cambridge, Cambridge, UK.
  • Demeter F; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
  • Sørensen L; Swiss Institute of Bioinformatics, University of Lausanne, Lausanne, Switzerland.
  • Nielsen PO; Department of Historical Studies, University of Gothenburg, Gothenburg, Sweden.
  • Henriksen RA; Department of Integrative Biology, University of California, Berkeley, CA, USA.
  • Vimala T; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
  • McColl H; GeoGenetics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
  • Margaryan A; Research Department of Genetics, Evolution and Environment, University College London, London, UK.
  • Ilardo M; Department of Archaeology, University of Cambridge, Cambridge, UK.
  • Vaughn A; Laboratory of Biological Anthropology, Department of Forensic Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Fischer Mortensen M; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
  • Nielsen AB; Muséum National d'Histoire Naturelle, CNRS, Université de Paris, Musée de l'Homme, Paris, France.
  • Ulfeldt Hede M; The National Museum of Denmark, Copenhagen, Denmark.
  • Johannsen NN; The National Museum of Denmark, Copenhagen, Denmark.
  • Rasmussen P; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
  • Vinner L; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
  • Renaud G; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
  • Stern A; Section for Evolutionary Genomics, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
  • Jensen TZT; Centre for Evolutionary Hologenomics, University of Copenhagen, Copenhagen, Denmark.
  • Scorrano G; Anthropology Department, University of Utah, Salt Lake City, UT, USA.
  • Schroeder H; Center for Computational Biology, University of California, Berkeley, CA, USA.
  • Lysdahl P; The National Museum of Denmark, Copenhagen, Denmark.
  • Ramsøe AD; Department of Geology, Lund University, Lund, Sweden.
  • Skorobogatov A; Tårnby Gymnasium og HF, Kastrup, Denmark.
  • Schork AJ; Department of Archaeology and Heritage Studies, Aarhus University, Aarhus, Denmark.
  • Rosengren A; The National Museum of Denmark, Copenhagen, Denmark.
  • Ruter A; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
  • Outram A; Department of Health Technology, Section of Bioinformatics, Technical University of Denmark, Kongens Lyngby, Denmark.
  • Timoshenko AA; Center for Computational Biology, University of California, Berkeley, CA, USA.
  • Buzhilova A; Section for Evolutionary Genomics, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
  • Coppa A; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
  • Zubova A; Section for Evolutionary Genomics, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
  • Silva AM; Vendsyssel Historiske Museum, Hjørring, Denmark.
  • Hansen AJ; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
  • Gromov A; Terra Ltd., Voronezh, Russian Federation.
  • Logvin A; Department of Genetics, University of Cambridge, Cambridge, UK.
Nature ; 625(7994): 301-311, 2024 Jan.
Article em En | MEDLINE | ID: mdl-38200295
ABSTRACT
Western Eurasia witnessed several large-scale human migrations during the Holocene1-5. Here, to investigate the cross-continental effects of these migrations, we shotgun-sequenced 317 genomes-mainly from the Mesolithic and Neolithic periods-from across northern and western Eurasia. These were imputed alongside published data to obtain diploid genotypes from more than 1,600 ancient humans. Our analyses revealed a 'great divide' genomic boundary extending from the Black Sea to the Baltic. Mesolithic hunter-gatherers were highly genetically differentiated east and west of this zone, and the effect of the neolithization was equally disparate. Large-scale ancestry shifts occurred in the west as farming was introduced, including near-total replacement of hunter-gatherers in many areas, whereas no substantial ancestry shifts happened east of the zone during the same period. Similarly, relatedness decreased in the west from the Neolithic transition onwards, whereas, east of the Urals, relatedness remained high until around 4,000 BP, consistent with the persistence of localized groups of hunter-gatherers. The boundary dissolved when Yamnaya-related ancestry spread across western Eurasia around 5,000 BP, resulting in a second major turnover that reached most parts of Europe within a 1,000-year span. The genetic origin and fate of the Yamnaya have remained elusive, but we show that hunter-gatherers from the Middle Don region contributed ancestry to them. Yamnaya groups later admixed with individuals associated with the Globular Amphora culture before expanding into Europe. Similar turnovers occurred in western Siberia, where we report new genomic data from a 'Neolithic steppe' cline spanning the Siberian forest steppe to Lake Baikal. These prehistoric migrations had profound and lasting effects on the genetic diversity of Eurasian populations.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Genoma Humano / Metagenômica / Migração Humana / Genética Populacional Limite: Humans País como assunto: Asia / Europa Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Genoma Humano / Metagenômica / Migração Humana / Genética Populacional Limite: Humans País como assunto: Asia / Europa Idioma: En Ano de publicação: 2024 Tipo de documento: Article