Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase.
J Enzyme Inhib Med Chem
; 39(1): 2301767, 2024 Dec.
Article
em En
| MEDLINE
| ID: mdl-38205514
ABSTRACT
Cell division cycle 7 kinase (CDC7) has been found overexpressed in many cancer cell lines being also one of the kinases involved in the nuclear protein TDP-43 phosphorylation in vivo. Thus, inhibitors of CDC7 are emerging drug candidates for the treatment of oncological and neurodegenerative unmet diseases. All the known CDC7 inhibitors are ATP-competitives, lacking of selectivity enough for success in clinical trials. As allosteric sites are less conserved among kinase proteins, discovery of allosteric modulators of CDC7 is a great challenge and opportunity in this field.Using different computational approaches, we have here identified new druggable cavities on the human CDC7 structure and subsequently selective CDC7 inhibitors with allosteric modulation mainly targeting the pockets where the interaction between this kinase and its activator DBF4 takes place.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Nucleares
/
Proteínas Serina-Treonina Quinases
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article