Severe depression and all-cause and cause-specific mortality in Scotland: 20 year national cohort study.
BJPsych Open
; 10(1): e28, 2024 Jan 11.
Article
em En
| MEDLINE
| ID: mdl-38205603
ABSTRACT
BACKGROUND:
Understanding cause of death in people with depression could inform approaches to reducing premature mortality.AIM:
To describe all-cause and cause-specific mortality for people with severe depression in Scotland, by sex, relative to the general population.METHOD:
We performed a retrospective cohort study, using psychiatric hospital admission data linked to death data, to identify adults (≥18 years old) with severe depression and ascertain cause-specific deaths, during 2000-2019. We estimated relative all-cause and cause-specific mortality for people with severe depression using standardised mortality ratios (SMRs), stratified by sex using the whole Scottish population as the standard.RESULTS:
Of 28 808 people with severe depression, 7903 (27.4%) died during a median follow-up of 8.7 years. All-cause relative mortality was over three times higher than expected (SMR, both sexes combined 3.26, 95% CI 3.19-3.34). Circulatory disease was the leading cause of death, and, among natural causes of death, excess relative mortality was highest for circulatory diseases (SMR 2.51, 2.40-2.66), respiratory diseases (SMR 3.79, 3.56-4.01) and 'other' causes (SMR 4.10, 3.89-4.30). Among circulatory disease subtypes, excess death was highest for cerebrovascular disease. Both males and females with severe depression had higher all-cause and cause-specific mortality than the general population. Suicide had the highest SMR among both males (SMR 12.44, 95% CI 11.33-13.54) and females (22.86, 95% CI 20.35-25.36).CONCLUSION:
People with severe depression have markedly higher all-cause mortality than the general population in Scotland, with relative mortality varying by cause of death. Effective interventions are needed to reduce premature mortality for people with severe depression.
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Base de dados:
MEDLINE
Tipo de estudo:
Etiology_studies
/
Observational_studies
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article